DNA & Genes
CONCEPTUALDescribe the double helix structure of DNA (base pairs, complementarity), explain how genes are sections of DNA that code for proteins, introduce the central dogma (DNA → mRNA → protein) conceptually, and discuss the ethical implications of CRISPR gene editing — including potential benefits (genetic disease treatment) and concerns (germline editing, 'designer babies')
Mastery Evidence
- Describes DNA as a double helix with four bases (A, T, C, G) where A pairs with T and C pairs with G
- Explains that a gene is a section of DNA that codes for a specific protein, and that proteins carry out most of the body's functions
- Describes CRISPR as a molecular tool that can cut and edit DNA sequences, and raises at least two distinct ethical considerations about its use in humans
Assessment Prompt
“If [child] heard that scientists have edited a human gene to prevent a hereditary disease, could they explain what DNA actually is, how genes work, and why some people think editing human DNA raises serious ethical questions?”
Prerequisites1
- Chromosomes, Genes & DNAhardAges 12—13
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- Chromosomes, Genes & DNA hard
DNA structure and replication depends on chromosomes and Mendelian inheritance
- Cells Under the Microscope hard
DNA is housed in the nucleus of cells — the cell as fundamental unit must be understood before studying what's inside the nucleus
Unlocks2
- Predicting Inherited TraitssoftAges 13—14
- Cancer & Stem CellshardAges 13—14